abstract：HEADING AIMS:MicroRNA-27b (miR-27b) has been shown to play a role in the progression of many different forms of cancer, but its specific relevance in the context of non-small cell lung cancer (NSCLC) remains uncertain. As such, this study sought to explore the role of miR-27b in NSCLC and the mechanisms whereby it func...

journal_title：Life sciences

authors： Zhang J,Hua X,Qi N,Han G,Yu J,Yu Y,Wei X,Li H,Chen X,Leng C,Liu Q,Lu Y,Li Y

更新日期：2020-08-01 00:00:00

abstract：AIMS:Rg1 is the most active component of traditional Chinese medicine ginseng, having anti-aging and anti-oxidative stress features in multiple organs. Cellular senescence of hepatocytes is involved in the progression of a wide spectrum of chronic liver diseases. In this study, we investigated the potential benefits an...

journal_title：Life sciences

authors： Qi R,Jiang R,Xiao H,Wang Z,He S,Wang L,Wang Y

更新日期：2020-08-01 00:00:00

abstract：AIM:MicroRNAs (miRNAs) function as oncogenes or tumor suppressors in an extensive variety of human cancers, including prostate cancer (PCa). Herein, the aim of this study is to investigate the effect of miR-381 on autophagy and apoptosis of PCa cells through the reelin (RELN)-mediated the PI3K/AKT/mTOR signaling pathwa...

journal_title：Life sciences

authors： Liao W,Zhang Y

更新日期：2020-08-01 00:00:00

abstract：:Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic components to furnish additional energy. It has cytoprotective effects through the degradation of intracellular pathogens, damaged organelles, and protein aggregates. On the other hand, there are reports of an association between...

journal_title：Life sciences

authors： Karami J,Masoumi M,Khorramdelazad H,Bashiri H,Darvishi P,Sereshki HA,Shekarabi M,Sahebkar A

更新日期：2020-08-01 00:00:00

abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...

journal_title：Life sciences

authors： Kumari P,Roy K,Wadhwa M,Chauhan G,Alam S,Kishore K,Ray K,Panjwani U

更新日期：2020-08-01 00:00:00

abstract：AIMS:There have been recent reports that reconsolidation-based interventions attenuate drug reward memories in rodents. The insular cortex (IC) is an essential part of neural circuits that underlie cue-drug memory reconsolidation. GABAergic interneurons in the IC are a potent control on network excitability and play an...

journal_title：Life sciences

authors： Sun K,Xiao L,Wu Y,Zuo D,Zhang C,Liu S,He Z,Rong S,Wang F,Sun T

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...

journal_title：Life sciences

authors： Li J,Li B,Bai F,Ma Y,Liu N,Liu Y,Wang Y,Liu Q

更新日期：2020-08-01 00:00:00

abstract：HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...

journal_title：Life sciences

authors： Yue J,Zhu T,Yang J,Si Y,Xu X,Fang Y,Fu W

更新日期：2020-07-15 00:00:00

abstract：:Despite considerable progressions, cardiovascular disease (CVD) is still one of the major causes of mortality around the world, indicates an important and unmet clinical need. Recently, extensive studies have been performed on the role of inflammatory factors as either a major or surrogate factor in the pathophysiolog...

journal_title：Life sciences

authors： Soroureddin Z,Nouri-Vaskeh M,Maleki M,Baghbanzadeh A,Hajiasgharzadeh K,Taban Sadeghi M,Baradaran B

更新日期：2020-07-15 00:00:00

abstract：AIMS:Recently, the zebrafish has gained attention as an innovative experimental model to decipher molecular and cellular mechanisms involved in cardiovascular development and diseases. Nevertheless, the use of zebrafish models has been challenged because the transparency of these fish, which allows for accurate cardiac...

journal_title：Life sciences

authors： Fang Y,Sun Y,Luo C,Gu J,Shi Z,Lu G,Silvestre JS,Chen Z

更新日期：2020-07-15 00:00:00

abstract：AIMS:Multiple sclerosis (MS) whose pathogenesis is still unclear is a chronic progressive disease in the central nervous system. Gut microbiota can directly or indirectly affect the immune system through the brain gut axis to engage in the occurrence and development of the disease. MATERIALS AND METHODS:C57BL/6 mice w...

journal_title：Life sciences

authors： Xu L,Zhang C,He D,Jiang N,Bai Y,Xin Y

更新日期：2020-07-15 00:00:00

abstract：AIMS:Studies indicate that the pattern of shear stress determines the direction of endothelial progenitor cells (EPCs) differentiation. However, the mechanism remains largely unknown. Herein, we try to identify the role of oscillatory shear stress (OSS) in the transdifferentiation of EPCs into mesenchymal cells and the...

journal_title：Life sciences

authors： Gao Y,Cui X,Wang M,Zhang Y,He Y,Li L,Li H,Zhang X,Cheng M

更新日期：2020-07-15 00:00:00

abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

journal_title：Life sciences

authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

更新日期：2020-07-15 00:00:00

abstract：AIMS:To determine whether ginsenoside Rg1 is involved in scratch wound healing through altered expression of related molecules in astrocytes and improved functional recovery after spinal cord injury (SCI). MATERIALS AND METHODS:Astrocytes were isolated from rats, followed by Rg1 treatment. The wound healing test was p...

journal_title：Life sciences

authors： Xu L,Tang YY,Ben XL,Cheng MH,Guo WX,Liu Y,Lu ZF,Deng JL

更新日期：2020-07-01 00:00:00

abstract：:Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and neuroprotective effects. The present study aims to investigate the antidepressant effe...

journal_title：Life sciences

authors： Jiang N,Lv J,Wang H,Huang H,Wang Q,Lu C,Zeng G,Liu XM

更新日期：2020-07-01 00:00:00

abstract：AIMS:To identify the target of an adipose specific aptamer adipo-8, predict the potential interaction between adipo-8 and its target, and investigate lipid-lowering effect of adipo-8 in vitro and in vivo. MAIN METHODS:Distinct membranous protein of 3T3-L1 adipocyte pulled-down by adipo-8 was mass-spectrometry analyzed...

journal_title：Life sciences

authors： Zhong W,Zhang Y,Tan W,Zhang J,Liu J,Wang G,Liao J,Liu B,Chen K,Yu B,Deng Y,Zou Y,Pu Y,Liu H

更新日期：2020-06-15 00:00:00

abstract：AIM:Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced nephrotoxicity (GIN). MAIN METHODS:Male Wistar rats were treated with gentamicin with/out AR ligands (testosterone as agonist and flutamide as antagonist). Megalin expr...

journal_title：Life sciences

authors： Elsakka EGE,Elsisi AM,Mansour OAA,Elsadek BEM,Abd Elaziz AI,Salama SA,Allam S

更新日期：2020-06-15 00:00:00

abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

journal_title：Life sciences

authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

更新日期：2020-06-15 00:00:00

abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...

journal_title：Life sciences

authors： Zhao Y,Shen F,Gong M,Jin L,Ren X,Liu K,Lu J

更新日期：2020-06-15 00:00:00

abstract：AIMS:Sarcopenia is characterized by muscle mass and strength loss and reduced physical activity. Branched-chain amino acids (BCAAs) were recently described as an activator of protein synthesis via mammalian target of rapamycin (mTOR) signaling for muscle atrophy. In cardiovascular diseases, excessive activation of the ...

journal_title：Life sciences

authors： Yamanashi K,Kinugawa S,Fukushima A,Kakutani N,Takada S,Obata Y,Nakano I,Yokota T,Kitaura Y,Shimomura Y,Anzai T

更新日期：2020-06-01 00:00:00

abstract：AIM:Nontuberculous mycobacterial (NTM) infection such as endophthalmitis, dacryocystitis, and canaliculitis are pervasive across the globe and are currently managed by antibiotics. However, the recent cases of Mycobacteroides developing drug resistance reported along with the improper practice of medicine intrigued us ...

journal_title：Life sciences

authors： Satyam R,Bhardwaj T,Jha NK,Jha SK,Nand P

更新日期：2020-06-01 00:00:00

abstract：:Aim Determine changes in the expressions of the ion channel-TRPV1-and neuropeptides-NKA, NKB, calcitonin gene-related peptide (CGRP), and SP-in 14-, 21-, and 42-day-old rats after inhaling 1.5% and 2.6% sevoflurane. MAIN METHODS:A small in-house inhalation anesthesia chamber was designed to allow 14-, 21-, and 42-day...

journal_title：Life sciences

authors： Liu D,Yuan J,Fei X,Zhu Y,Zhou Y,Zhang C,Dong L,Zhu Z

更新日期：2020-05-15 00:00:00

abstract：:Brown adipose tissue (BAT) has multiple functions in the human body, including the production of heat and increasing energy consumption. However, BAT is also related to many kinds of diseases, such as obesity and metabolic disorders. The progression of such diseases occurs at the cellular level, and thus, imaging tech...

journal_title：Life sciences

authors： Gu J,Wang X,Yang H,Li H,Wang J

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND:Gastric cancer is a severe disease with a high occurrence rate worldwide. And lncRNAs are demonstrated to be responsible for cancer growth and metastasis. So, it is of great importance to explore the lncRNAs involved mechanism of gastric cancer occurrence and development deeply. METHODS:Transfection was con...

journal_title：Life sciences

authors： Zhang XZ,Mao HL,Zhang SJ,Sun L,Zhang WJ,Chen QZ,Wang L,Liu HC

更新日期：2020-05-15 00:00:00

abstract：AIMS:Nanoparticles (NPs)-based drugs have been recently introduced to improve the efficacy of current therapeutic strategies for the treatment of cancer; however, the molecular mechanisms by which a NP interacts with cellular systems still need to be delineated. Here, we utilize the autophagic potential of TiO2 NPs for...

journal_title：Life sciences

authors： Azimee S,Rahmati M,Fahimi H,Moosavi MA

更新日期：2020-05-01 00:00:00

abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...

journal_title：Life sciences

authors： Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SA

更新日期：2020-04-15 00:00:00

abstract：:Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...

journal_title：Life sciences

authors： Tu CC,Wan BY,Zeng Y

更新日期：2020-04-15 00:00:00

abstract：AIMS:Gastric cancer (GC) is one of the most common malignant tumors in the world. Anti-angiogenic therapy is a useful strategy for the treatment of advanced GC. This study was aimed to systemically compare the anti-angiogenesis, anti-cancer efficacy, as well as the safety of four known anti-angiogenic drugs, namely ram...

journal_title：Life sciences

authors： Wu JQ,Fan RY,Zhang SR,Li CY,Shen LZ,Wei P,He ZH,He MF

更新日期：2020-04-15 00:00:00

abstract：:Although both the incidence and the mortality rate of breast cancer is rising, there is no potent and practical option for the treatment of these patients, particularly in advanced stages. One of the most critical challenges for treatment is the presence of complicated and extensive tumor escape mechanisms in the tumo...

journal_title：Life sciences

authors： Bastaki S,Irandoust M,Ahmadi A,Hojjat-Farsangi M,Ambrose P,Hallaj S,Edalati M,Ghalamfarsa G,Azizi G,Yousefi M,Chalajour H,Jadidi-Niaragh F

更新日期：2020-04-15 00:00:00

abstract：AIMS:Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide. Decrease in NKG2D ligand levels and exhaustion of NK cells in HCC patients are major causes of immune escape, high recurrence, poor prognosis, and low overall survival. Enhancing the susceptibility of HCC to NK cells by upregulating N...

journal_title：Life sciences

authors： Bian J,He L,Wu Y,Liu W,Ma H,Sun M,Yu J,Yu Z,Wei M

更新日期：2020-04-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects. MAIN METHODS:Adult male Wistar rats were exposed to ethan...

journal_title：Life sciences

authors： Mouton AJ,El Hajj EC,Ninh VK,Siggins RW,Gardner JD

更新日期：2020-03-15 00:00:00

abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...

journal_title：Life sciences

authors： Satomi S,Morio A,Miyoshi H,Nakamura R,Tsutsumi R,Sakaue H,Yasuda T,Saeki N,Tsutsumi YM

更新日期：2020-03-15 00:00:00

abstract：AIMS:Schisandra is a good choice in Traditional Chinese Medicine for the therapy of cardiovascular diseases, but whether it contains a or some specific component (s) responsible these effects are still unclear. In the present study, we explored whether Schisantherin A (SCA) causes vasorelaxation in isolated rat thoraci...

journal_title：Life sciences

authors： Yang S,Xu Z,Lin C,Li H,Sun J,Chen J,Wang C

更新日期：2020-03-15 00:00:00

abstract：:Secreted frizzled-related protein 5 (Sfrp5) primarily acts in combination with wingless-type family member 5a (Wnt5a), to inhibits chronic inflammation and repress atherosclerosis and other metabolic disorders. Epicardial adipose tissue (EAT), surrounding the heart and coronary arteries, has been found to be highly re...

journal_title：Life sciences

authors： Tong S,Du Y,Ji Q,Dong R,Cao J,Wang Z,Li W,Zeng M,Chen H,Zhu X,Zhou Y

更新日期：2020-03-15 00:00:00

abstract：:Neurodegenerative diseases need the drugs to be delivered right inside the brain to maximizing the therapeutic effects. This can be achieved by use of novel targeted delivery systems such as nanoemulsions. Nanoemulsions (NE) are nano-sized emulsions that are manufactured for enhancing the delivery of drugs to the targ...

journal_title：Life sciences

authors： Nirale P,Paul A,Yadav KS

更新日期：2020-03-15 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the possible antioxidant role of oleic acid (OA) against Cd-induced injuries in the heart and liver tissues of male Wistar rats. MAIN METHODS:Rats were treated with either vehicle (control), or OA (10 mg/kg b.w., fed orally), or Cd (0.44 mg/kg b.w., s.c.), or both (OA ...

journal_title：Life sciences

authors： Bhattacharjee B,Pal PK,Chattopadhyay A,Bandyopadhyay D

更新日期：2020-03-01 00:00:00

abstract：AIMS:Microvascular endothelial cell dysfunction is a leading cause of radiation-induced heart disease (RIHD). BRCA1 plays an important role in DNA damage repair. The study aims to explore the effect of BRCA1 in endothelial cells involved in RIHD. MATERIALS AND METHODS:BRCA1 and p21 expression were detected in human um...

journal_title：Life sciences

authors： Zeng ZM,Du HY,Xiong L,Zeng XL,Zhang P,Cai J,Huang L,Liu AW

更新日期：2020-03-01 00:00:00

abstract：:More than 140 thousands of women suffer from endometrial carcinoma in the worldwide, and over 40 thousand of the patients die before and after in surgery and chemoradiotherapy because of its metastasis. However, its molecular mechanism is much less known compared to other cancers. In this study, we demonstrated that l...

journal_title：Life sciences

authors： Zhang C,Shao S,Zhang Y,Wang L,Liu J,Fang F,Li P,Wang B

更新日期：2020-02-15 00:00:00

abstract：AIMS:Chemo-resistance still was the main obstacle for AML patients, more effective and less toxic forms of therapies were desperately needed. Metformin, a classic hypoglycemic drug for diabetes recently delivered us a new identity that it exerted anti-tumor activity through suppressing mTOR in various tumors. But the a...

journal_title：Life sciences

authors： Yuan F,Cheng C,Xiao F,Liu H,Cao S,Zhou G

更新日期：2020-02-15 00:00:00